GLOBAL OFFICES

Shoden

Clinical Science:

Anti-inflammtory

W. somnifera was reported to reduce inflammation by inhibiting cyclooxygenase

Restorative Sleep

WS treatment was also found to suppress corticosterone release and activate choline acetyltransferase enzyme, which in turn increase serotonin levels in hippocampus. WS extract reportedly binds to synaptic/extra synaptic GABAA receptors in hippocampal CA1 pyramidal neurons and induced remarkable inward currents, thereby maintaining the neurons in a depolarized state that may contribute to neuroprotection. The neuroprotective effect of WS extracts on hippocampal neurons has also been reported to be effective in in sleep-deprived condition

Immunomodulation

The leaf and root extract of W. somnifera was shown to activate immune system by selectively augmenting Th1 immune response

Anti-Stress & anti-Depression

Withanolide glycosides isolated from the whole plant W. somnifera root extract has a significant anti-stress and adaptogenic effect. Anti-anxiety effects of W. somnifera are possibly due to its GABA (Gamma Amino-butyric acid)-like activity. GABA, is an inhibitory neurotransmitter which functions by attenuating the neuron activity and suppresses the nerve cells from over firing. Ashwagandha-derived bioactive glycowithanolides was found to reduce the levels of tribulin (i.e. an anxiety marker)